Palmitoylethanolamide (PEA) (PEA) Capsules in Pakistan
A naturally occurring fatty acid amide, PEA is an endogenous lipid modulator found in foods like egg yolks, peanuts, and soybeans, as well as in human tissues. It is renowned for its anti-inflammatory, analgesic, and neuroprotective properties, making it a popular supplement for chronic pain, nerve-related conditions, and immune support.
Key Benefits & Clinical Applications:
Chronic Pain Relief:
Reduces pain intensity in conditions like osteoarthritis, fibromyalgia, sciatica, and neuropathic pain (e.g., diabetic neuropathy, carpal tunnel syndrome) 138.Meta-analyses show PEA significantly lowers pain scores compared to placebos, with a standard mean difference of 1.68 (95% CI: 1.05–2.31) 3.
Neuroprotection & Brain Health:
Supports neuroinflammation modulation and may aid in neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s) by targeting PPAR-α receptors and reducing glial cell activation.
Immune & Mast Cell Regulation:
Inhibits mast cell degranulation, reducing inflammation in allergies, asthma, and autoimmune conditions.
Detox & Liver Support:
Enhances cellular resilience against toxins and oxidative stress.
Mechanisms of Action:
PPAR-α Activation: Modulates gene expression to reduce inflammation and pain signaling.
Endocannabinoid Entourage Effect: Indirectly boosts anandamide (AEA) levels, enhancing CB1/CB2 receptor activity.
TRPV1 Channel Modulation: Desensitizes pain receptors and reduces nociception.
Dosage & Administration:
Adults: 300–1200 mg/day, typically split into 2–3 doses (e.g., 400 mg 3x daily). Optimal effects may take 4–12 weeks.
Micronized PEA: Enhanced bioavailability (e.g., 600 mg capsules) for faster absorption.
Take with food (especially healthy fats) to improve absorption.
.jpg)
.jpg)
.jpg)
.jpg)
.jpg)
.jpg)
.jpg)
.jpg)
.jpg)
.jpg)
.jpg)
.jpg)
.jpg)
1.jpg)
.jpg)
.jpg)
.jpg)
.jpg)
_600mg_Capsule.jpg)
